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Here we present very fast algorithms to estimate the dates and substitution rates on phylogenetic trees when the sequences have been sampled through time.These algorithms are based on a Gaussian model closely related to the Langley-Fitch molecular-clock model.Practically any drug (administered openly or surreptitiously) that facilitates rape could be considered a date rape drug.Since the mid-1990s, the media and researchers have documented a new form of DFSA featuring date rape drugs such as rohypnol and ketamine.A 2009 Australian study found that of 97 instances of patients admitted to hospital believing their drinks might have been spiked, illicit drugs were detected in 28% of samples, and nine cases were identified as "plausible drink spiking cases".This study defined a "plausible drink spiking case" in such a way that cases where (a) patients believed that their drink had been spiked, and (b) lab tests showed agents that patients said they had not ingested would still be ruled out as plausible if the patient did not also (c) exhibit "signs and symptoms" that were considered "consistent with agents detected by laboratory screening." The drug most commonly used to facilitate sexual assault is alcohol, consumed voluntarily.This drug is also known as Whitleys, Trip-and-Fall, Ruffies, Rophies, Rope, Roopies, Roofies, Roches, Roach-2, Roach, Mind Erasers, Rib, Lunch Money, R-2, Poor Man’s Quaalude, Mexican Valium, LA Rochas, Forget Pill, and Circles. When slipped into a drink, a dye in these new pills makes clear liquids turn bright blue and dark drinks turn cloudy.

In 65% of the 1014 cases included in this study, testing could not be conducted within a time frame that would allow detection of GHB.Other tests for Rohypnol include blood and hair tests.